First hotfix already out, apparently addresses launch crash issues particularly for legacy AMD users and Nvidia users.
It's kinda crap that they shafted Nvidia 3D users. I can understand how they feel since that's pretty much been the experience with PhysX on non-Nvidia cards.
So far I have very few gripes with the game, they're all technicalities really. Visually, it's not ground-breaking and every once in a while I'll come across a lo-res texture. It seems like the graphics have been scaled back to accommodate the consoles, even with DX11 activated it has minor flaws that really show some design cut-backs (low-poly models, helmet-hair, etc.) There are a few technical glitches here and there, like if something in the background (e.g. Skype or TeamViewer) has a notification it somehow takes priority over the game and it gets minimized, or the visuals get really pixelated (similar to half-resolution effect), but I can easily alt-tab and it goes back to normal. Also, the v-sync needs some work, it makes my framerate very erratic; switching it off is the way to go.
The controls are well done but even then it took me a few minutes to adjust to the mouse aim movement, it feels like something that was designed for an analogue stick but functions with the mouse (like Halo PC). End of the day it is a port, but it's the best damn port I've seen! A great example of how console-to-PC ports should be done.
Now that I've got the negative out of the way, DX:HR is a phenomenal game. The art and style make up for any technical shortcomings. The sound, music, and ambiance are mesmerizing. They all come together to make a highly immersive experience; I have trouble letting go! The best part for me is that it's giving me that feeling of excitement I used to have for games. It's coming back! hehe I think Que will appreciate this

Anyway, I will fill you all in on some more impressions as I play through the game.